Euthyroid

Euthyroid Collaboration

Publications


Publications: thyroid hormones

  1. Williams FLR, Hume R.  The measurement, definition, aetiology and clinical consequences of neonatal transient hypothyroxinaemia.  Ann Clin Biochem 7th October 2010 as doi:10.1258/acb.2010.010174.
  2. Delahunty C, Falconer S, Hume R, Jackson L, Midgley P, Mirfield M, Ogston S, Perra O, Simpson J, Watson J, Willatts P, Williams FLR and the Scottish Preterm Thyroid Group.  Levels of neonatal thryoid hormone in preterm infants and neurodevelopmental outcome at 5½ years:  Millenium cohort study.  J Clin Endocrinol Metab August 18th, 2010 as doi:10.1210/jc.2010-07
  3. Hume R, Williams FLR.  Iodine deficiency due to parenteral nutrition.  In: Comprehensive Handbook on Iodine: Nutritional, Endocrine and Pathological Aspects.  Preedy VR, Burrow GN, Watson RR. (Eds) Ch 40.  2009.
  4. Hume R, Lang K, Williams FLR. Iodine deficiency due to artificial enteral nutritional support.  In: Comprehensive Handbook on Iodine: Nutritional, Endocrine and Pathological Aspects.  Preedy VR, Burrow GN, Watson RR. (Eds) Ch 41.  2009.
  5. Williams FLR, Hume R. (2008)  Perinatal factors affecting thyroid hormone status in extreme preterm infants.  Sem Perinatol 32:398-402.
  6. Williams FLR, Visser TJ, Hume R. (2006) Transient hypothyroxinaemia in preterm infants. Early Hum Devel 82:797-802.
  7. Stanley EL, Hume R, Coughtrie MWH. (2005) Expression profiling of human fetal cytosolic sulfotransferases involved in steroid and thyroid hormone metabolism and in detoxification. Mol Cell Endocrinol 240:32-42
  8. Williams FLR, Ogston SA, van Toor H, Visser TJ, Hume R. (2005) Serum thyroid hormones in preterm infants; associations with postnatal illnesses and drug usage. J Clin Endocrinol Metab 90:5954-5963.
  9. Williams FLR, Mires GJ, Barnett C, Ogston SA, van Toor H, Visser TJ, Hume R (2005) Transient hypothyroxinaemia in preterm infants; the role of cord sera thyroid hormone levels adjusted for prenatal and intrapartum factors. J Clin Endocrinol Metab 90:4599-4606.
  10. Simpson J, Williams FLR, Delahunty C, Ogston SA, van Toor H, Wu S-Y, Visser TJ, Hume R with collaboration from the Scottish Preterm Thyroid Group. (2005) Serum thyroid hormones in preterm infants and relationships to indices of severity of intercurrent illness. J Clin Endocrinol Metab 90, 1271-1279
  11. Hume R, Williams FLR, Visser TJ (2005) Transient hypothyroxinaemia and preterm infant brain development. Thyroid International 2.
  12. Stanley EL, Hume R and Coughtrie MWH (2005) Sulfotransferases in the human fetus and neonate. In Cytosolic human sulfotransferases Eds Pacifici GM and Coughtrie MWH Taylor and Francis, London. pp 105-120.
  13. Stanley EL, Hume R, Coughtrie MWH. (2005) Expression profiling of human fetal cytosolic sulfotransferases involved in steroid and thyroid hormone metabolism and in detoxification. Mol Cell Endocrinol 240:232-242.
  14. Murphy N, Hume R, van Toor H, Matthews TG, Wu S-Y, Visser TJ, Williams FLR (2004) The hypothalamic-pituitary-thyroid axis in preterm infants; responsiveness to birth over the first 24 hours of life. J Clin Endocrinol Metab 89(6):2824–2831.
  15. Hume R, Simpson J, Delahunty C, van Toor H, Wu S-Y, Williams FLR, Visser TJ with collaboration from the Scottish Preterm Thyroid Group. (2004) Human fetal and cord serum thyroid hormones: developmental trends and inter-relationships. J Clin Endocrinol Metab 89: 4097–4103.
  16. Williams FLR, Simpson J, Delahunty C, Ogston SA, Bongers-Schokking JJ, Murphy N, van Toor H, Wu S-Y, Visser TJ, Hume R with collaboration from the Scottish Preterm Thyroid Group. (2004) Developmental trends in cord and postpartum serum thyroid hormones in preterm infants. J Clin Endocrinol Metab 89:5314-5320
  17. Kester MHA, de Mena RM, Obregon MJ, Marinkovic D, Howatson A, Visser TJ, Hume R, Morreale de Escobar GM. (2004) Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas. J Clin Endocrinol Metab 89:3117-3128
  18. Hume R. (2003) Neurodisability: metabolic and hormonal aspects. Dev Med Child Neurol 45: 14-17 Suppl 95.
  19. Ibrahim M, Morreale de Escobar G, Visser TJ, Durán S, van Toor H, Strachan J, Williams FLR, Hume R (2003) Iodine deficiency associated with parenteral nutrition in extreme preterm infants. Arch Dis Child.88:F56–F57.
  20. Hume R. (2002) Iodothyronine metabolism and human brain. In “Thyroid and Brain” eds Morreale de Escobar G, de Vijlder JJM, Butz S, Hostalek U. Merck European Thyroid Symposium, Sevilla Schattauer Verlag, Stuttgart pp 189-195
  21. Hume R. (2002) “Iodothyronine metabolism and human brain. In “Thyroid and Brain” eds Morreale de Escobar G, de Vijlder JJM, Butz S, Hostalek U. Merck European Thyroid Symposium, Sevilla Schattauer Verlag, Stuttgart pp 189-195.
  22. Hume R. (2002) Thyroid hormones and lung development (editorial website European Thyroid Association) www.hotthyroidology.com
  23. Barnett CA, Visser TJ, Williams F, van Toor H, Duran S, Presas MJ, Morreale de Escobar G, Hume R. Inadequate iodine intake of 40% of pregnant women from a region in Scotland. J Endocrinol Invest 2002; 25 (Suppl): 90.
  24. Stanley EL, Hume R, Visser TJ, Coughtrie MWH. sulfotransferases enzymes involved in thyroid hormone metabolism during human placental development J Clin Endocrinol Metab. 86: 5944-5955.
  25. Hume R, Richard K, Kaptein E, Stanley EL, Visser TJ, Coughtrie MWH (2001) Thyroid hormone metabolism and the developing human lung. Biol Neonate 80 (supplement 1):18-21.
  26. Richard K, Hume R, Kaptein E, Stanley EL, Visser TJ, Coughtrie MWH. (2001) Sulfation of thyroid hormone and dopamine during human development-ontogeny of phenol sulfotransferases and arylsulfatase in liver, lung and brain J Clin Endocrinol Metab . 86:2734-2742
  27. Delahunty C, Simpson J, Richard K, Coughtrie M, Williams FW, Murphy N, Matthews T, Visser T, Hume R. (2001) Transient hypothyroxinemia in preterm infants Developmental Medicine and Child Neurology Supplement Neuroprotection of the Infant Brain 43: 26-27 Suppl. 86.
  28. Hume R, Richard K, Kaptein E, Stanley EL, Visser TJ, Coughtrie MWH (2001) Thyroid hormone metabolism and the developing human lung. Biol Neonate 2001;80 (suppl 1): 18–21.
  29. Murphy N, Delahunty C, Richard K, Matthews T, Coughtrie M, Visser T, Hume R. (2000) Iodothyronine metabolism and human brain development. Ambulatory Child Health 6 Supplement 1, 15-16
  30. Richard K, Hume R, Kaptein E, Sanders JP, de Herder WW, den Hollander JC, Krenning EP, and Visser TJ. (1998) Ontogeny of type I and type III iodothyronine deiodinases in human liver. J Clin Endocrinol Metab 83, 2868-2874.
  31. Forfar JO, Hume R, McPhail FM, Maxwell SM, Wilkinson EM, Lin J-P and Brown JK. (1994) Low birthweight : A ten year outcome study of the continuum of reproductive casualty. Dev. Med. Child Neurol. 36: 1037-1048.

Top


Publications: glucose metabolism

  1. Forsyth L, Scott HM, Howatson A, Busuttil A, Hume R, Burchell A (2007) Genetic variation in hepatic glucose-6-phosphatase system genes in cases of sudden infant death syndrome. J Path 212:112-120.
  2. Forsyth L, Hume R, Howatson A, Busuttil A, Burchell A. (2005) Identification of novel polymorphisms in the glucokinase and glucose-6-phosphatase genes in infants who died suddenly and unexpectedly. J Mol Med 83:610-618
  3. Hume R, Burchell A, Williams FLR, Koh DKM (2005) Glucose homeostasis in the newborn. Early Human Development 81, 95—101
  4. Jackson L, Williams FLR, Burchell A, Coughtrie MWH, Hume R(2004) Plasma catecholamines and the counter-regulatory responses to hypoglycaemia in infants: a critical role for epinephrine and cortisol. J Clin Endocrinol Metab 89:6251 – 6256
  5. Jackson L, Burchell A, McGeechan A, Hume R (2003)An inadequate glycaemic response to glucagon is linked to insulin resistance in preterm infants? Arch Dis Child. 88:F62-F66
  6. Hume R, McGeechan A, Burchell A (2000) Perinatal factors influencing hepatic glucose-6-phosphatase enzyme activity. J Perinatology .20: 301-306
  7. Burchell A, McGeechan A, Hume R (2000) Therapeutic insulin and hepatic glucose-6-phosphatase enzyme activity in preterm infants. Arch Dis Child Fetal Neonatal Ed. 82: F228-F232
  8. Hume R, McGeechan A and Burchell A (1999) Failure to detect preterm infants at risk of hypoglycaemia prior to discharge home. J Pediatr 134, 499-502
  9. Clarke DJ, Moghrabi N, Monaghan G, Cassidy A, Boxer M, Hume R,Burchell B (1997) Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias Clinica Chimica Acta 266, 63-74
  10. Burchell A, Watkins SL, Hume R(1996) The human fetal testis endoplasmic reticulum glucose-6-phosphatase enzyme protein. Biology of Reproduction 55, 298-303
  11. Hume R, Burchell A (1996). The glucose-6-phosphatase enzyme in developing human trachea and oesophagus. Histochemical J. 28,141-147
  12. Hume R, Voice M, Pazouki S, Giunti R, Benedetti A and Burchell A (1995) The human adrenal microsomal glucose-6-phosphatase system J. Clin. Endocrinol. Metab. 80: 1960-1966
  13. Burchell A, Allan BB, Hume R (1994) The endoplasmic reticulum glucose-6-phosphatase proteins. Molecular Membrane Biology 11: 217-227
  14. Steel JM, Johnstone FD, Hume R, Mao J-H (l994). Insulin requirements during pregnancy in insulin dependent diabetic women. Obstet. Gynecol. 83:253-258
  15. Hume R, Bell J, Hallas A and Burchell A. (1994) Immunohistochemical localisation of glucose-6-phosphatase in developing human kidney. Histochemistry 101: 413-417
  16. Lyall H, Burchell A, Howie PW, Ogston S, Hume R. (l994). Early detection of metabolic abnormalities in preterm infants impaired by disorders of blood glucose concentration. Clin. Chem. 40, 526-530
  17. Bell JE, Hume R, Busuttil A and Burchell A (l993). Immunocytochemical detection of the microsomal glucose-6-phosphatase in human brain astrocytes. Neuropath. Appl. Neurobiol. 19, 429-435
  18. Hume R, Burchell A (l993). Abnormal expression of glucose-6-phosphatase in preterm infants. Arch. Dis. Child. 68, 202-204
  19. Burchell A, Lyall, H, Busuttil A, Bell J, Hume R (l992). Glucose metabolism and Hypoglycaemia in SIDS. J. Clin. Pathol. 45, (supplement): 39-45
  20. Nordlie RC, Scott HM, Waddell ID, Hume R, Burchell A. (1992) Analysis of human hepatic microsomal glucose-6-phosphatase in clinical conditions where the T2 pyrophosphate/phosphate transport protein is absent. Biochem. J. 281, 859-863
  21. Hume R, Lyall H, Burchell A. (l992) Impairment of the activity of the microsomal glucose-6-phosphatase system in premature infants. Acta Paediatr. 81, 580-584
  22. Coughtrie MWH, Blair JNR, Hume R, Burchell A. (1991) Improved procedure for the preparation of hepatic microsomes to be used in the in-vitro diagnosis of inherited disorders of the glucose-6-phosphatase system. Clin. Chem. 37, 739-742
  23. Burchell A, Gibb L, Waddell ID, Giles M, Hume R (1990) The ontogeny of the human hepatic microsomal glucose-6-phosphatase proteins. Clin. Chem. 36, 1633-1637
  24. Coughtrie MWH, Ask B, Rane A, Burchell B, Hume R (1989) The enantioselective glucuronidation of morphine in rats and humans. Biochem. Pharmacol. 38: 3273-3280
  25. Burchell A, Bell JE, Busuttil A, Hume R  (1989) The hepatic microsomal glucose-6-phosphatase system in cases of sudden infant death syndrome. Lancet ii, 291-294
  26. Burchell A, Waddell ID, Stewart L, Hume R (1989) Perinatal diagnosis of type 1c glycogen storage disease. J. Inher. Metab. Dis. 12, 315-317
  27. Waddell ID, Hume R, Burchell A (1989) A direct method for the diagnosis of human hepatic type 1b and 1c glycogen storage disease. Clin. Sci. 76: 573-579
  28. Burchell A, Waddell ID, Countaway JL, Arion WJ, Hume R (1988) Identification of human hepatic microsomal glucose-6-phosphatase enzyme. FEBS Lett. 242: 153-156
  29. Coughtrie MWH, Burchell B, Leakey JEA, Hume R (1988) The inadequacy of perinatal glucuronidation. Immunoblot analysis of the developmental expression of individual UDP-glucuronosyl transferase isoenzymes in rat and human liver microsomes. Mol. Pharm. 34: 729-735
  30. Burchell A, Hume R, Burchell B (1988) A new microtechnique for the analysis of the human hepatic microsomal glucose-6-phosphatase system. Clin. Chem. Acta. 173: 183-192

Top

Click here for the list of publications in PDF format

Click here for link to electronic database

Contact us at euthyroid@chs.dundee.ac.uk